It is critical that the debates leading up to the re-opening of South Africa’s schools, and the actual process of re-opening, which will almost certainly occur in stages, be informed by the emerging medical evidence and reports on best school practices. Re-opening the pre-school sector, covering around 2.4 million children, and the earliest school grades, seems least risky in terms of infections. Moreover, there are strong educational and nutritional arguments which favour prioritising these levels.